Progesterone Excess: Symptoms, Causes, and Treatment

Fatigue, mood swings, depression – the symptoms of a progesterone excess are similar to those of a progesterone dominance. But how does a progesterone excess arise? Here you can find out everything about symptoms, causes and treatment.

Progesterone, along with estrogen, is one of the most important female sex hormones. The corpus luteum hormone is particularly dominant in the second half of the cycle. It is especially important for women who want to have children as it prepares the uterus for the fertilized egg cell to implant. In addition, it ensures that the body temperature increases and the glands in the chest condense. During the menopause, the progesterone level drops sharply, which leads to typical menopausal symptoms such as sleep disorders and mood swings.

What is Progesterone Excess?

Certain causes can cause the level of progesterone in the blood to be too high. In this case the symptoms are very similar to those of a deficiency. This is because a prolonged excess of hormones can develop hormone resistance. This means that the body cells no longer react to the respective hormone and deficiency symptoms occur despite an excessively high hormone level. In contrast to a progesterone deficiency, an excess of progesterone is rare.

Excess progesterone: These symptoms can occur




Mood swings


Weight gain

These are the reasons for an excess of progesterone:

The progesterone level must always be viewed in the context of the female cycle, as the concentration of progesterone fluctuates greatly over the course of the cycle. Causes that can cause excessively high progesterone levels are:

Hormone therapies: Hormone therapy can lead to excess progesterone. For example, progesterone-deficient women who want to have children often take progesterone to reduce the risk of miscarriage. Hormone therapy with progesterone is also common in menopausal women and in women who have had their ovaries surgically removed.

Menstrual cycle disorders: Menstrual cycle disorders can also be a cause of an excess of progesterone if the corpus luteum does not regress at the end of the second phase of the cycle and progesterone is continuously produced.

Medication: Taking drugs that contain progesterone, such as the pill, can also lead to excess progesterone.

Adrenogenital Syndrome (AGS): The adrenogenital syndrome can also lead to an excess of progesterone. It refers to a disorder in the production of hormones in the adrenal gland that results in an overproduction of sex hormones.

How is excess progesterone treated?

A blood test by your doctor can determine whether you have excess progesterone. If that is the case, then the cause must be treated. For example, in the case of hormone therapy, the hormone dose must be adjusted or the therapy terminated.

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